Brian Fowler Selected Research

cobamamide (adenosylcobalamin)

9/2014	Characterization of functional domains of the cblD (MMADHC) gene product.
1/2013	Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type.
8/2007	Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB).
10/2004	The cblD defect causes either isolated or combined deficiency of methylcobalamin and adenosylcobalamin synthesis.

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Brian Fowler Research Topics

Disease

10	Methylmalonic acidemia 01/2017 - 10/2004
8	Homocystinuria 01/2017 - 02/2004
7	Hyperhomocysteinemia 01/2020 - 11/2003
6	Methylenetetrahydrofolate reductase deficiency 12/2017 - 06/2002
4	Human Influenza (Influenza) 01/2016 - 08/2012
2	Infections 01/2022 - 08/2012
2	Muscle Hypotonia (Hypotonia) 01/2017 - 01/2016
2	Late Onset Disorders 03/2016 - 01/2013
2	Inborn Errors Metabolism (Inborn Errors of Metabolism) 09/2014 - 08/2007
2	Propionic Acidemia 09/2014 - 06/2004
2	Methylmalonic acidemia with homocystinuria 01/2013 - 07/2009
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2005 - 05/2005
2	Seizures (Absence Seizure) 11/2004 - 02/2003
1	Lacrimal Duct Obstruction 01/2022
1	Graves Ophthalmopathy 12/2021
1	Optic Nerve Diseases (Optic Neuropathy) 12/2021
1	Diplopia (Double Vision) 12/2021
1	Exophthalmos (Proptosis) 12/2021
1	Cardiotoxicity 10/2021
1	Heart Failure 10/2021
1	Cardiomyopathies (Cardiomyopathy) 10/2021
1	Myocarditis (Carditis) 10/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2021
1	Systolic Heart Failure 10/2021
1	Lacrimal Apparatus Diseases (Epiphora) 04/2020
1	Muscle Weakness 01/2020
1	Amyloidosis 11/2019
1	Spinal Cord Diseases 01/2016
1	Epilepsy (Aura) 01/2016
1	Hydrocephalus (Hydrocephaly) 01/2016
1	Brain Diseases (Brain Disorder) 01/2016
1	Intellectual Disability (Idiocy) 01/2016
1	Mental Disorders (Mental Disorder) 01/2016
1	Ataxia (Dyssynergia) 01/2016
1	Microcephaly 01/2016
1	Sepsis (Septicemia) 01/2016
1	Pulmonary Embolism 01/2016
1	Respiratory Insufficiency (Respiratory Failure) 01/2016
1	Virus Diseases (Viral Diseases) 07/2014
1	Lung Diseases (Lung Disease) 10/2013
1	Abdominal Aortic Aneurysm 04/2013
1	Metabolic Diseases (Metabolic Disease) 01/2013
1	Rett Syndrome (Rett's Disorder) 07/2011
1	Chorioretinitis 01/2011
1	Anemia 05/2010
1	Cognitive Dysfunction 05/2010
1	Dementia (Dementias) 09/2009
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 09/2009
1	Dihydropyrimidine Dehydrogenase Deficiency 06/2009
1	Chronic Kidney Failure (Chronic Renal Failure) 08/2007
1	Parkinson Disease (Parkinson's Disease) 11/2005

Drug/Important Bio-Agent (IBA)

11	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 11/2013 - 08/2002
9	HomocysteineIBA 01/2017 - 11/2003
6	Folic Acid (Vitamin M)FDA LinkGeneric 12/2017 - 11/2003
5	Methionine (L-Methionine)FDA Link 01/2016 - 10/2004
4	Methylmalonyl-CoA MutaseIBA 01/2016 - 08/2007
4	Antiviral Agents (Antivirals)IBA 01/2016 - 08/2012
4	cobamamide (adenosylcobalamin)IBA 09/2014 - 10/2004
3	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2020 - 01/2016
3	5,10-methylenetetrahydrofolic acidIBA 05/2016 - 06/2002
3	Oxidoreductases (Dehydrogenase)IBA 05/2016 - 06/2002
3	EnzymesIBA 01/2016 - 11/2003
3	Methylmalonic AcidIBA 09/2014 - 05/2005
3	mecobalamin (methylcobalamin)IBA 01/2013 - 10/2004
3	Biotin (Vitamin H)FDA Link 11/2004 - 07/2002
2	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)IBA 01/2013 - 03/2005
2	CreatineIBA 07/2011 - 02/2003
2	Proteins (Proteins, Gene)FDA Link 04/2009 - 06/2004
2	S-Adenosylmethionine (Ademetionine)IBA 11/2005 - 05/2005
2	Vitamin B Complex (B Vitamins)IBA 05/2005 - 05/2005
1	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/2022
1	SiliconesIBA 01/2022
1	teprotumumabIBA 12/2021
1	Tyrosine Kinase InhibitorsIBA 10/2021
1	fms-Like Tyrosine Kinase 3IBA 10/2021
1	gilteritinibIBA 10/2021
1	Immunoglobulins (Immunoglobulin)IBA 11/2019
1	Hydroxocobalamin FDA Link 03/2016
1	PropionatesIBA 01/2016
1	Propionyl-Coenzyme A Carboxylase (Propionyl CoA Carboxylase)IBA 09/2014
1	propionic acid (potassium propionate)IBA 09/2014
1	Oseltamivir (Tamiflu)FDA Link 07/2014
1	VitaminsIBA 11/2013
1	Amino Acids FDA Link 01/2013
1	Coenzymes (Enzyme Cofactors)IBA 01/2013
1	SteroidsIBA 01/2011
1	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 06/2009
1	Antineoplastic Agents (Antineoplastics)IBA 06/2009
1	Fluorouracil (Carac)FDA LinkGeneric 06/2009
1	pyrimidineIBA 06/2009
1	Levodopa (L Dopa)FDA LinkGeneric 11/2005
1	hydroxide ionIBA 10/2005

Therapy/Procedure

4	Therapeutics 12/2021 - 11/2004
3	Length of Stay 01/2016 - 01/2014
1	Stents 01/2022
1	Operative Time 04/2020
1	General Anesthesia 04/2020
1	Artificial Respiration (Mechanical Ventilation) 01/2016
1	Transcatheter Aortic Valve Replacement 04/2013
1	Endovascular Aneurysm Repair 04/2013